Isotope by Metafizzy is a jQuery plugin that can be integrated with any Genesis theme to enable dynamic filtering of posts by category in a masonry-based layout on the blog page (including category query-strings). Masonry is maintained on search and other archive pages (e.g. tags), as is the Isotope category/search menu. However, clicking on Isotope menu items returns the user back to the blog page for filtering.
Here’s a demo with the functionality in its rawest form using the Genesis Sample theme.